Cyclin E2 antibody (C-Term)

Catalog No. ABIN1679046

The Rabbit Polyclonal anti-Cyclin E2 antibody (ABIN1679046) specifically detects Cyclin E2 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Cyclin E2 antibody (C-Term) (ABIN1679046)

Target: Cyclin E2 (CCNE2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin E2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Cyclin E2 Antibody

Binding Specificity: C-Term

Sequence: ALCHFTSIEV VKKASGLEWD SISECVDWMV PFVNVVKSTS PVKLKTFKKI PMEDRHNIQT HTNYLAMLEE VNYINTFRKG GQLSPVCNGG IMTPPKSTEK PPGKH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human Cyclin E2 (NP_477097.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Cyclin E2

Target: Cyclin E2 (CCNE2)

Alternative Name: CCNE2

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.,CCNE2,CYCE2,cyclin E2,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cyclins,G1/S Checkpoint,Hedgehog Signaling Pathway,CCNE2

Molecular Weight: 41 kDa/46 kDa

Gene ID: 9134

UniProt: O96020

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases