PPARGC1B antibody

Catalog No. ABIN1680494

The Rabbit Monoclonal anti-PPARGC1B antibody is suitable to detect PPARGC1B in samples from Human. It has been validated for WB.

Quick Overview for PPARGC1B antibody (ABIN1680494)

Target: PPARGC1B (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 beta (PPARGC1B))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PPARGC1B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PPARGC1B Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human PGC1 beta

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PPARGC1B

Target: PPARGC1B (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 beta (PPARGC1B))

Alternative Name: PPARGC1B

Background: The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],ERRL1, PERC, PGC-1(beta), PGC1B,Cardiovascular,Endocrine & Metabolism,Endocrine and metabolic diseases,Endocrine and metabolic diseases_Diabetes,Epigenetics & Nuclear Signaling,Lipids,Lipids_Fatty Acids,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial markers,Nuclear Receptor Signaling,PPARGC1B

Molecular Weight: 113 kDa

Gene ID: 133522

UniProt: Q86YN6

Pathways: AMPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha