LARP1 antibody

Catalog No. ABIN1680662

The Rabbit Polyclonal anti-LARP1 antibody is suitable to detect LARP1 in samples from Human. It has been validated for WB.

Quick Overview for LARP1 antibody (ABIN1680662)

Target: LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LARP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LARP1 Antibody

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant Protein of human LARP1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LARP1

Target: LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))

Alternative Name: LARP1

Background: RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.,LARP1,LARP,Epigenetics & Nuclear Signaling,RNA Binding,LARP1

Molecular Weight: 116 kDa/123 kDa

Gene ID: 23367

UniProt: Q6PKG0

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection