Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

LARP1 antibody

LARP1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3019027
$426.53
Plus shipping costs $45.00
Shipping to: United States
Delivery in 10 to 11 Business Days
  • Target See all LARP1 Antibodies
    LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))
    Reactivity
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 13
    • 2
    Rabbit
    Clonality
    • 15
    Polyclonal
    Application
    • 15
    • 3
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB)
    Cross-Reactivity
    Human
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant Protein of human LARP1
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))
    Alternative Name
    LARP1 (LARP1 Products)
    Synonyms
    RGD1306683, wu:fb92d03, wu:fd15e07, 3110040D16RIK, MGC98945, LARP, 1810024J12Rik, 3110040D16Rik, Larp, mKIAA0731, La ribonucleoprotein domain family, member 1, La ribonucleoprotein domain family member 1, La ribonucleoprotein domain family member 1 L homeolog, Larp1, larp1, LARP1, larp1.L
    Background
    RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.,LARP1,LARP,Epigenetics & Nuclear Signaling,RNA Binding,LARP1
    Molecular Weight
    116 kDa/123 kDa
    Gene ID
    23367
    UniProt
    Q6PKG0
    Pathways
    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
You are here:
Support