This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],IRAK, pelle,Cardiovascular,Cell Intrinsic Innate Immunity Signaling Pathway,Cytokines,Cytokines_Interleukins,Immunology & Inflammation,Innate Immunity_TLR Signaling,Kinase,Kinase_Serine/threonine kinases,NF-kB Signaling Pathway,Signal Transduction,Toll-like Receptor Signaling Pathway,IRAK1