BRCA1 antibody (pSer1466) (AbBy Fluor® 350)

Catalog No. ABIN1692844

This Rabbit Polyclonal antibody specifically detects BRCA1 in IF (p). It exhibits reactivity toward Human.

Quick Overview for BRCA1 antibody (pSer1466) (AbBy Fluor® 350) (ABIN1692844)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA1 antibody is conjugated to AbBy Fluor® 350

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-BRCA1 Antibody (AbBy Fluor® 350)

Binding Specificity: pSer1466

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1466

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Alternative Name: Brca1

Background:

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].

Synonyms: BRCA1 phospho S1466, BRCA1 phospho Ser1466, p-BRCA1 S1466, p-BRCA1 Ser1466, p-BRCA1 phospho S1466, BRCA1Ser1423, BRCA 1, BRCA1, BRCA1/BRCA2 containing complex subunit 1, BRCA1/BRCA2-containing complex, subunit 1, BRCA1_HUMAN, BRCAI, BRAC 1, BRCA 1, BRCC 1, BRCC1, Breast Cancer 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, Breast and ovarian cancer susceptibility protein 1, Breast Ovarian Cancer Susceptibility, IRIS, Papillary Serous Carcinoma Of The Peritoneum, PSCP, RING finger protein 53, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, RNF53, BAP1.

Gene ID: 672

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus