p130 antibody (AA 51-150) (AbBy Fluor® 488)

Catalog No. ABIN1695622

This Rabbit Polyclonal antibody specifically detects p130 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for p130 antibody (AA 51-150) (AbBy Fluor® 488) (ABIN1695622)

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p130 antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-p130 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 51-150

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Rb2 p130

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for p130

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Alternative Name: Rb2 p130

Background:

Synonyms: 130 kDa retinoblastoma associated protein, FLJ26459, p130, PRB 2, PRB2, Rb 2, Rb2, RBL2, RBR 2, RBR2, Retinoblastoma like 2, Retinoblastoma like protein 2, Retinoblastoma Related Gene.

Background: p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors.

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases