FOXO4 antibody (pThr451) (AbBy Fluor® 555)

Catalog No. ABIN1697516

The Rabbit Polyclonal anti-FOXO4 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect FOXO4 in samples from Human and Rat.

Quick Overview for FOXO4 antibody (pThr451) (AbBy Fluor® 555) (ABIN1697516)

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO4 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-FOXO4 Antibody (AbBy Fluor® 555)

Binding Specificity: pThr451

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human FOXO4 around the phosphorylation site of Thr451

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FOXO4

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Alternative Name: FOXO4

Background:

Synonyms: FOXO4 phospho T451,p-FOXO4 phospho T451, AFXSer197, Fork head domain transcription factor AFX1, AFX, AFX1, Afxh, ALL1-fused gene from X chromosome, Fork head domain transcription factor AFX1, Forkhead box O4, Forkhead box protein O4, FOXO 4, Mixed lineage leukemia, translocated to, 7, MLLT7, Myeloid lymphoid or mixed lineage leukemia translocated to 7, Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7, Putative fork head domain transcription factor AFX1, FOXO4_HUMAN.

Background: FOXO4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

Gene ID: 4303

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation