CEP57 antibody (AA 51-150) (Biotin)

Catalog No. ABIN1700243

Product Details anti-CEP57 Antibody (Biotin)

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Binding Specificity: AA 51-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP57 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CEP57

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CEP57

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Alternative Name: CEP57 (CEP57 Products)

Synonyms: 3110002L15RIK antibody, CEP57 antibody, cep57r antibody, xCep57 antibody, c6orf182 antibody, 3110002l15rik antibody, RGD1309884 antibody, 3110002L15Rik antibody, 4921510P06Rik antibody, 4931428M20Rik antibody, AI467480 antibody, Tsp57 antibody, mKIAA0092 antibody, MVA2 antibody, PIG8 antibody, TSP57 antibody, centrosomal protein 57 antibody, centrosomal protein 57kDa-like 1 antibody, CEP57 antibody, cep57l1 antibody, Cep57 antibody

Background:

Synonyms: Centrosomal protein 57 kDa, Centrosomal protein of 57 kDa, Cep57, Cep57 protein, CEP57_HUMAN, FGF2 interacting protein, FGF2-interacting protein, KIAA0092, MVA2, PIG8, proliferation inducing protein 8, Testis specic protein 57, Testis-specic protein 57, Translokin, TSP57.

Background: CEP57 (centrosomal protein 57 kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88 % sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.

Pathways: M Phase, Maintenance of Protein Location, Protein targeting to Nucleus, Growth Factor Binding