APC2 antibody (AA 1-100) (Biotin)

Catalog No. ABIN1701088

This Rabbit Polyclonal antibody specifically detects APC2 in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for APC2 antibody (AA 1-100) (Biotin) (ABIN1701088)

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-APC2 Antibody (Biotin)

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APCL/APC2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Alternative Name: APCL/APC2

Background:

Synonyms: Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APCL, APC2_HUMAN.

Background: The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner?s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin.

Gene ID: 10297

Pathways: WNT Signaling