APC2 antibody (Middle Region)

Catalog No. ABIN2784219

The Rabbit Polyclonal anti-APC2 antibody (ABIN2784219) specifically detects APC2 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Dog, Cow and Guinea Pig samples.

Quick Overview for APC2 antibody (Middle Region) (ABIN2784219)

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-APC2 Antibody

Binding Specificity: Middle Region

Sequence: LAVARIDQLV EDISALHTSS DDSFSLSSGD PGQEAPREGR AQSCSPCRGP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against APC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human APC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2303 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Alternative Name: APC2

Background: APC2 belongs to the adenomatous polyposis coli (APC) family. It contains 6 ARM repeats. APC2 promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. It may function in Wnt signaling.
Alias Symbols: APCL
Protein Interaction Partner: CTNNB1, NFX1, UBC, CDC27, ANAPC4, ANAPC10, CDC16, CDC23, ANAPC11, ANAPC7, ANAPC5, CDC26, CDH1, ANAPC1, MAPRE3, MAPRE1, Axin1, AXIN2, ACTA1,
Protein Size: 2303

Molecular Weight: 244 kDa

Gene ID: 10297

NCBI Accession: NM_005883, NP_005874

UniProt: Q9UJX6

Pathways: WNT Signaling