TSC1 antibody (AA 701-800) (Cy5)
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- Target See all TSC1 Antibodies
- TSC1 (Tuberous Sclerosis 1 (TSC1))
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Binding Specificity
- AA 701-800
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TSC1 antibody is conjugated to Cy5
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Hamartin
- Isotype
- IgG
- Top Product
- Discover our top product TSC1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TSC1 (Tuberous Sclerosis 1 (TSC1))
- Alternative Name
- Hamartin (TSC1 Products)
- Synonyms
- LAM antibody, TSC antibody, hamartin antibody, mKIAA0243 antibody, tsc1 antibody, wu:fc38b04 antibody, fa99f04 antibody, wu:fa99f04 antibody, zgc:63657 antibody, TSC complex subunit 1 antibody, tuberous sclerosis 1 antibody, TSC complex subunit 1b antibody, TSC complex subunit 1a antibody, TSC1 antibody, Tsc1 antibody, tsc1b antibody, tsc1 antibody, tsc1a antibody
- Background
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Synonyms: Hamartin, kiaa0243, LAM, TSC, TSC1, Tsc1 gene, TSC1_HUMAN, Tuberous sclerosis 1, Tuberous sclerosis 1 protein.
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC, one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.
- Gene ID
- 7248
- Pathways
- RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation
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