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FRAT1 antibody (AA 161-260) (HRP)

This Rabbit Polyclonal antibody specifically detects FRAT1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.
Catalog No. ABIN1712053

Quick Overview for FRAT1 antibody (AA 161-260) (HRP) (ABIN1712053)

Target

See all FRAT1 Antibodies
FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))

Reactivity

  • 25
  • 2
  • 1
Human

Host

  • 24
  • 1
Rabbit

Clonality

  • 23
  • 2
Polyclonal

Conjugate

  • 12
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This FRAT1 antibody is conjugated to HRP

Application

  • 25
  • 13
  • 13
  • 7
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 14
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 161-260

    Predicted Reactivity

    Human,Mouse,Rat,Dog,Cow

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human FRAT1

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))

    Alternative Name

    FRAT1

    Background

    Synonyms: FRAT 1, frequently rearranged in advanced T cell lymphomas, Frequently rearranged in advanced T-cell lymphomas, GSK 3 binding protein FRAT1, proto oncogene FRAT1, FRAT1_HUMAN.

    Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

    Gene ID

    10023
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