CYP51A1 antibody (AA 411-503) (HRP)

Catalog No. ABIN1712236

This Rabbit Polyclonal antibody specifically detects CYP51A1 in IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for CYP51A1 antibody (AA 411-503) (HRP) (ABIN1712236)

Target: CYP51A1 (Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 (CYP51A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP51A1 antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CYP51A1 Antibody (HRP)

Binding Specificity: AA 411-503

Purpose: CYP51A1 Polyclonal Antibody, HRP Conjugated

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CYP51A1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CYP51A1

Target: CYP51A1 (Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 (CYP51A1))

Alternative Name: CYP51A1

Background:

Synonyms: Lanosterol 14-alpha demethylase, LDM, CYPLI, Cytochrome P450 51A1, Cytochrome P450-14DM, Cytochrome P45014DM, Cytochrome P450LI, Sterol 14-alpha demethylase, CP51A_HUMAN.

Background: CYP51A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID: 1595