GHRHR antibody (HRP)

Catalog No. ABIN1712319

Product Details anti-GHRHR Antibody (HRP)

Target: GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GHRHR antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GHRHR

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GHRHR

Target: GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))

Alternative Name: GHRHR (GHRHR Products)

Synonyms: GHRFR antibody, GRFR antibody, IGHD1B antibody, Ghrfr antibody, lit antibody, little antibody, GHRHREC antibody, GHRH-R antibody, growth hormone releasing hormone receptor antibody, GHRHR antibody, Ghrhr antibody

Background:

Synonyms: GHRFR, GHRH R, GHRH receptor, Ghrhr, GHRHR_HUMAN, GHRHRpsv, GRF R, GRF receptor, GRFR, Growth hormone releasing factor receptor, Growth hormone releasing hormone receptor, Growth hormone-releasing factor receptor, Growth hormone-releasing hormone receptor.

Background: GHRH-R is a seven transmembrane domain protein that localizes to the somatotroph of the pituitary. GHRH-R plays an important role in growth and acts as a high-affinity receptor for GHRH. Binding of GHRH leads to the coupling of GHRH-R to G-protein which stimulates increased adenylyl cyclase activity and the accumulation of cAMP leading to the synthesis and release of growth hormone and somatotroph proliferation. In addition, this signalling pathway may have direct action in fetal/placental development, reproduction and immune function. GHRH and GHRH-R may also play a role in the regulation of non-rapid eye movement sleep (NREMS). The expression of GHRH-R is dependent on the presence of the POU domain factor Pit-1. Mutations in the gene encoding this protein can result in isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, and anterior pituitary hypoplasia (APH).

Gene ID: 2692

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Hormone Transport, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process