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DMP1 antibody (AA 221-320)

DMTF1 Reactivity: Human WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1713485
  • Target See all DMP1 (DMTF1) Antibodies
    DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
    Binding Specificity
    • 15
    • 14
    • 11
    • 10
    • 8
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 221-320
    Reactivity
    • 91
    • 19
    • 19
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    Human
    Host
    • 81
    • 7
    • 3
    • 1
    Rabbit
    Clonality
    • 86
    • 6
    Polyclonal
    Conjugate
    • 36
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This DMP1 antibody is un-conjugated
    Application
    • 67
    • 42
    • 25
    • 25
    • 8
    • 5
    • 5
    • 3
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DMP1
    Isotype
    IgG
    Top Product
    Discover our top product DMTF1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Zhan, Liu, Wang: "The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." in: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 536-546, (2018) (PubMed).

  • Target
    DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
    Alternative Name
    DMP1 (DMTF1 Products)
    Synonyms
    DMP1 antibody, DMTF antibody, hDMP1 antibody, Dimp antibody, Dmp1 antibody, DMTF1 antibody, zgc:92448 antibody, cyclin D binding myb like transcription factor 1 antibody, cyclin D binding myb-like transcription factor 1 antibody, DMTF1 antibody, Dmtf1 antibody, dmtf1 antibody
    Background

    Synonyms: ARHP, ARHR, AV020965, Dentin matrix acidic phosphoprotein 1, Dentin matrix protein 1, DENTMAT, DMP 1, Dmp, MGC130441, PP, Serine rich acidic phosphoprotein, DMP1_HUMAN.

    Background: DMP-1 is a member of the small integrin ligand N-linked glycoprotein family. It is important for the mineralization of bone and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It is synthesized by preosteoblasts and contains a large number of acidic domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where it functions as a transcriptional regulator for osteoblast-specific gene activation and induces osteoblast differentiation. During osteoblast maturation, DMP-1 undergoes a conformational change and becomes phosphorylated by casein kinase II in response to an influx of calcium ions to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM) where it regulates the nucleation of hydroxyapatite and the formation of calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal fragments in the ECM of bone and dentin. The protein has also been identified in bone as a high molecular weight proteoglycan comprised of the N-terminal DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in hypomineralized bone.

    Gene ID
    1758
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