POLM antibody (AA 261-360)

Catalog No. ABIN1713765

This anti-POLM antibody is a Rabbit Polyclonal antibody detecting POLM in WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) and ICC. Suitable for Human.

Quick Overview for POLM antibody (AA 261-360) (ABIN1713765)

Target: POLM (Polymerase (DNA Directed), mu (POLM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLM antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Product Details anti-POLM Antibody

Binding Specificity: AA 261-360

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DNA polymerase mu

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for POLM

Target: POLM (Polymerase (DNA Directed), mu (POLM))

Alternative Name: DNA polymerase mu

Background:

Synonyms: DNA Polymerase Mu, DNA-directed DNA polymerase mu, DNA-directed DNA/RNA polymerase mu, DPOLM_HUMAN, FLJ35482, Pol iota, Pol Mu, Polm, POLM protein, Polymerase DNA directed mu, Polymerase DNA directed mu, Tdt N, Tdt-N, TdtN, Terminal transferase.

Background: DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.

Gene ID: 27434

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response