BTBD14A antibody (AA 401-500)

Catalog No. ABIN1714041

The Rabbit Polyclonal anti-BTBD14A antibody (ABIN1714041) specifically detects BTBD14A in IF (cc), IF (p), IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for BTBD14A antibody (AA 401-500) (ABIN1714041)

Target: BTBD14A (BTB (POZ) Domain Containing 14A (BTBD14A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTBD14A antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-BTBD14A Antibody

Binding Specificity: AA 401-500

Purpose: BTBD14A Polyclonal Antibody

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BTBD14A

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BTBD14A

Target: BTBD14A (BTB (POZ) Domain Containing 14A (BTBD14A))

Alternative Name: BTBD14A

Background:

Synonyms: BTB POZ domain containing 14A, BTB domain containing 14A, BTB/POZ domain containing protein 14A, BTB/POZ domain-containing protein 14A, BTBD 14A, BTBD14, NAC-2, NACC2, NACC2_HUMAN, Nucleus accumbens-associated protein 2.

Background: BTBD14A is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.

Gene ID: 54813

Pathways: Positive Regulation of Response to DNA Damage Stimulus