TEK antibody (pTyr1108)

Catalog No. ABIN1714261

This Rabbit Polyclonal antibody specifically detects TEK in WB, ELISA, IF (cc), IF (p), ICC and IHC (fro). It exhibits reactivity toward Human and Rat.

Quick Overview for TEK antibody (pTyr1108) (ABIN1714261)

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TEK Antibody

Binding Specificity: pTyr1108

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human TIE2 around the phosphorylation site of Tyr1108

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Alternative Name: TIE2

Background:

Synonyms: p-TIE2 phospho Y1108, Angiopoietin-1 receptor, CD202b, CD202b antigen, Endothelial tyrosine kinase, Endothelium specic receptor tyrosine kinase 2, hTIE 2, hTIE2, hTIE2, Hyk, p140 TEK, p140 TEK, Tek, tek tyrosine kinase, TEK tyrosine kinase endothelial, tek tyrosine kinase, endothelial, TIE 2, TIE2_HUMAN, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains 2, Tyrosine protein kinase receptor TEK, Tyrosine protein kinase receptor TIE 2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, Venous malformations multiple cutaneous and mucosal, VMCM 1, VMCM, VMCM1.

Background: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations, the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.TEK is closely related to the TIE receptor tyrosine kinase.

Gene ID: 7010

Pathways: RTK Signaling, Growth Factor Binding