ATM antibody (full length)

Catalog No. ABIN1721458

This Mouse Monoclonal antibody specifically detects ATM in WB, IHC, ELISA, IF, IP, FACS, ICC and ChIP. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for ATM antibody (full length) (ABIN1721458)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)

Clone: 2C1

Product Details anti-ATM Antibody

Binding Specificity: AA 2577-3056, full length

Specificity: Reacts with human ATM. Cross-reacts with mouse, rat and monkey protein.

Purification: Purified

Immunogen: GST fusion protein expressed in E. coli corresponding to aa 2577- 3056 of full-length ATM.

Isotype: IgG1 kappa

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB1:500 - 1:3000 IHC-P5 μg/mL IP1 - 10 μg/mL.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C/-80 °C

Storage Comment: Stable for at least one year at -20°C or -70°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Alternative Name: ATM

Background: ATM is a 370 kD nuclear phosphoprotein,which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.

Serine-protein kinase ATM Ataxia telangiectasia mutated, A-T mutated gene name: ATM AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1

Gene ID: 472

UniProt: Q13315

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus