CDC25C antibody

Catalog No. ABIN1724739

Cited in 2+ publications. The Mouse Monoclonal anti-CDC25C antibody (Clone 1F12) (ABIN1724739) specifically detects CDC25C in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for CDC25C antibody (ABIN1724739)

Target: CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDC25C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 1F12

Product Details anti-CDC25C Antibody

Purpose: CDC25C Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CDC25C expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CDC25C antibody (ABIN1724739)

Zheng, Kosti, Loffredo, Bowman, Mechanic, Perlmutter, Jones, Shields, Harris: "Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 9, pp. 2199-210, (2010) (PubMed).

Busch, Barton, Morgenstern, Götz, Günther, Noll, Montenarh: "The G2/M checkpoint phosphatase cdc25C is located within centrosomes." in: The international journal of biochemistry & cell biology, Vol. 39, Issue 9, pp. 1707-13, (2007) (PubMed).

Target Details for CDC25C

Target: CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C))

Alternative Name: CDC25C

Background: Cdc25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It has been highly conserved during evolution and it plays a key role in the regulation of cell division. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Cdc25C is mainly expressed in G2 phase. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

Molecular Weight: 58 kDa

Gene ID: 995

UniProt: P30307

Pathways: Cell Division Cycle, M Phase