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PDE1B antibody (AA 370-536)

PDE1B Reactivity: Human ELISA, IHC, FACS Host: Mouse Monoclonal 5C4A3 unconjugated
Catalog No. ABIN1724781
  • Target See all PDE1B Antibodies
    PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))
    Binding Specificity
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 370-536
    Reactivity
    • 40
    • 24
    • 16
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 37
    • 8
    Mouse
    Clonality
    • 36
    • 9
    Monoclonal
    Conjugate
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PDE1B antibody is un-conjugated
    Application
    • 35
    • 23
    • 15
    • 10
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Purpose
    PDE1B Antibody
    Purification
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human PDE1B (AA: 370-536 ) expressed in E. Coli.
    Clone
    5C4A3
    Isotype
    IgG1
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Vandeput, Wolda, Krall, Hambleton, Uher, McCaw, Radwanski, Florio, Movsesian: "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes." in: The Journal of biological chemistry, Vol. 282, Issue 45, pp. 32749-57, (2007) (PubMed).

  • Target
    PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))
    Alternative Name
    PDE1B (PDE1B Products)
    Background
    The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

    Molecular Weight
    61.4 kDa
    Gene ID
    5153
    UniProt
    Q01064
    Pathways
    Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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