PDE1B antibody (AA 190-536)

Catalog No. ABIN3022918

This Rabbit Polyclonal antibody specifically detects PDE1B in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for PDE1B antibody (AA 190-536) (ABIN3022918)

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PDE1B Antibody

Binding Specificity: AA 190-536

Sequence: RHNLISRFKI PTVFLMSFLD ALETGYGKYK NPYHNQIHAA DVTQTVHCFL LRTGMVHCLS EIELLAIIFA AAIHDYEHTG TTNSFHIQTK SECAIVYNDR SVLENHHISS VFRLMQDDEM NIFINLTKDE FVELRALVIE MVLATDMSCH FQQVKTMKTA LQQLERIDKP KALSLLLHAA DISHPTKQWL VHSRWTKALM EEFFRQGDKE AELGLPFSPL CDRTSTLVAQ SQIGFIDFIV EPTFSVLTDV AEKSVQPLAD EDSKSKNQPS FQWRQPSLDV EVGDPNPDVV SFRSTWVKRI QENKQKWKER AASGITNQMS IDELSPCEEE APPSPAEDEH NQNGNLD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 190-536 of human PDE1B (NP_000915.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDE1B

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Alternative Name: PDE1B

Background: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.,PDE1B,HEL-S-79p,PDE1B1,PDES1B,Cell Biology & Developmental Biology,Apoptosis,PDE1B

Molecular Weight: 59 kDa/61 kDa

Gene ID: 5153

UniProt: Q01064

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma