Integrin Alpha2b antibody (AA 45-149)

Catalog No. ABIN1724822

The Mouse Monoclonal anti-Integrin Alpha2b antibody has been validated for FACS, IHC and ELISA. It is suitable to detect Integrin Alpha2b in samples from Human. There are 2+ publications available.

Quick Overview for Integrin Alpha2b antibody (AA 45-149) (ABIN1724822)

Target: Integrin Alpha2b (CD41)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA

Clone: 2E10C9

Product Details anti-Integrin Alpha2b Antibody

Binding Specificity: AA 45-149

Purpose: ITGA2B Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Integrin Alpha2b antibody (ABIN1724822)

Park, Chung, Lee, Park, Kim, Kim: "Novel and recurrent mutations of ITGA2B and ITGB3 genes in Korean patients with Glanzmann thrombasthenia." in: Pediatric blood & cancer, Vol. 59, Issue 2, pp. 335-8, (2012) (PubMed).

Nurden, Fiore, Nurden, Pillois: "Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models." in: Blood, Vol. 118, Issue 23, pp. 5996-6005, (2011) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: ITGA2B

Background: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Molecular Weight: 113.4 kDa

Gene ID: 3674

UniProt: P08514

Pathways: Integrin Complex