NG2 antibody (AA 2247-2308)

Catalog No. ABIN1724837

There are 2+ publications for this product available. The Mouse Monoclonal anti-NG2 antibody is suitable to detect NG2 in samples from Human. It has been validated for FACS and ELISA.

Quick Overview for NG2 antibody (AA 2247-2308) (ABIN1724837)

Target: NG2 (MCSP) (Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NG2 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: 7G4E5

Product Details anti-NG2 Antibody

Binding Specificity: AA 2247-2308

Purpose: CSPG4 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CSPG4 (AA: 2247-2308) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NG2 antibody (ABIN1724837)

Wang, Katayama, Wang, Yu, Favoino, Sakakura, Favole, Tsuchikawa, Silver, Watkins, Kageshita, Ferrone: "Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG4." in: Cancer research, Vol. 71, Issue 24, pp. 7410-22, (2011) (PubMed).

Price, Colvin Wanshura, Yang, Carlson, Xiang, Li, Ferrone, Dudek, Turley, McCarthy: "CSPG4, a potential therapeutic target, facilitates malignant progression of melanoma." in: Pigment cell & melanoma research, Vol. 24, Issue 6, pp. 1148-57, (2011) (PubMed).

Target Details for NG2

Target: NG2 (MCSP) (Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP))

Alternative Name: CSPG4

Background: A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.

Molecular Weight: 250.0 kDa

Gene ID: 1464

UniProt: Q6UVK1

Pathways: Glycosaminoglycan Metabolic Process