Osteoactivin (AA 31-260) antibody

Details for Product No. ABIN1724859
Antigen
Epitope
AA 31-260
15
10
8
7
5
4
4
3
3
2
2
2
1
1
1
Reactivity
Human
84
29
26
5
4
4
4
4
2
2
1
1
Host
Mouse
60
30
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
56
42
20
13
12
5
3
3
3
1
Options
Immunogen Purified recombinant fragment of human GPNMB (AA 31-260) expressed in E. Coli.
Clone 7C10E5
Isotype IgG1
Purification Purified
Antigen
Alternative Name GPNMB
Background The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. ,
Molecular Weight 64 kDa
Gene ID 10457
HGNC 10457
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Osteoactivin (AA 31-260) antibody (ABIN1724859) Immunohistochemical analysis of paraffin-embedded esophagus cancer tissues using GPNM...
Image no. 2 for anti-Osteoactivin (AA 31-260) antibody (ABIN1724859) Immunohistochemical analysis of paraffin-embedded breast cancer tissues using GPNMB m...
Product cited in: Tsui, Chang, Feng, Chang, Juang: "Glycoprotein transmembrane nmb: an androgen-downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells." in: The Prostate, Vol. 72, Issue 13, pp. 1431-42, 2012 (PubMed).

Williams, Esmaeli, Soheili, Simantov, Gombos, Bedikian, Hwu: "GPNMB expression in uveal melanoma: a potential for targeted therapy." in: Melanoma research, Vol. 20, Issue 3, pp. 184-90, 2010 (PubMed).