CD45 antibody (AA 928-989)

Catalog No. ABIN1724924

The Mouse Monoclonal anti-CD45 antibody has been validated for IHC and ELISA. It is suitable to detect CD45 in samples from Human. There are 2+ publications available.

Quick Overview for CD45 antibody (AA 928-989) (ABIN1724924)

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD45 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 5D3A3

Product Details anti-CD45 Antibody

Binding Specificity: AA 928-989

Purpose: PTPRC Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CD45 antibody (ABIN1724924)

Pujari, Eligar, Kumar, Nagre, Inamdar, Swamy, Shastry: "CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC." in: Biochemical and biophysical research communications, Vol. 419, Issue 4, pp. 708-14, (2012) (PubMed).

Gopal, Pagel, Fromm, Wilbur, Press: "131I anti-CD45 radioimmunotherapy effectively targets and treats T-cell non-Hodgkin lymphoma." in: Blood, Vol. 113, Issue 23, pp. 5905-10, (2009) (PubMed).

Target Details for CD45

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Alternative Name: PTPRC

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Molecular Weight: 147.3 kDa

Gene ID: 5788

UniProt: P08575

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling