CD45 antibody (AA 890-990)

Catalog No. ABIN3022954

The Rabbit Polyclonal anti-CD45 antibody is suitable to detect CD45 in samples from Human. It has been validated for IHC, WB and IF.

Quick Overview for CD45 antibody (AA 890-990) (ABIN3022954)

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD45 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CD45 Antibody

Binding Specificity: AA 890-990

Sequence: RCLMVQVEAQ YILIHQALVE YNQFGETEVN LSELHPYLHN MKKRDPPSEP SPLEAEFQRL PSYRSWRTQH IGNQEENKSK NRNSNVIPYD YNRVPLKHEL E

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 890-990 of human CD45 (NP_002829.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CD45

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Alternative Name: PTPRC

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.,B220,CD45,CD45R,GP180,L-CA,LCA,LY5,T200,PTPRC,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,CD markers,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Neuroscience,Cell Type Marker,Stem Cells,Hematopoietic Progenitors,Microglia marker,PTPRC

Molecular Weight: 130 kDa/147 kDa

Gene ID: 5788

UniProt: P08575

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling