CSF1R antibody (AA 344-497)

Catalog No. ABIN1724928

Product Details anti-CSF1R Antibody

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Binding Specificity: AA 344-497

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CSF1R antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human CSF1R (AA: 344-497) expressed in E. coli.

Clone: 6B9H2

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-CSF1R antibody (ABIN1724928)

Morandi, Barbetti, Riverso, Dello Sbarba, Rovida: "The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines." in: PLoS ONE, Vol. 6, Issue 11, pp. e27450, (2011) (PubMed).

Kitagawa, Gouda, Kirii, Sugiyama, Ishihama, Fujii, Narumi, Akita, Yokota: "Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase." in: Journal of biochemistry, Vol. 151, Issue 1, pp. 47-55, (2011) (PubMed).

Target Details for CSF1R

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Alternative Name: CSF1R (CSF1R Products)

Background:

Description: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. ,

Aliases: FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R

Molecular Weight: 108 kDa

Gene ID: 1436

HGNC: 1436

Pathways: RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization