EIF2A antibody (AA 448-576)

Catalog No. ABIN1724933

There are 2+ publications for this product available. The Mouse Monoclonal anti-EIF2A antibody is suitable to detect EIF2A in samples from Human, Mouse, Rat and Monkey. It has been validated for WB, IHC, ELISA and FACS.

Quick Overview for EIF2A antibody (AA 448-576) (ABIN1724933)

Target: EIF2A (Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A))

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This EIF2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 3A7B11

Product Details anti-EIF2A Antibody

Binding Specificity: AA 448-576

Purpose: EIF2A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human EIF2A (AA: 448-576) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-EIF2A antibody (ABIN1724933)

Yerlikaya, DoKudur: "Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells." in: Molekuliarnaia biologiia, Vol. 44, Issue 5, pp. 859-66, (2010) (PubMed).

Schewe, Aguirre-Ghiso: "Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy." in: Cancer research, Vol. 69, Issue 4, pp. 1545-52, (2009) (PubMed).

Target Details for EIF2A

Target: EIF2A (Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A))

Alternative Name: EIF2A

Background: EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes.

Molecular Weight: 65 kDa

Gene ID: 83939

UniProt: Q9BY44

Pathways: Ribonucleoprotein Complex Subunit Organization, ER-Nucleus Signaling, Hepatitis C, Methionine Biosynthetic Process, Ribosome Assembly