TRF2 antibody (AA 324-500)

Catalog No. ABIN1724941

This Mouse Monoclonal antibody specifically detects TRF2 in ELISA and IHC. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for TRF2 antibody (AA 324-500) (ABIN1724941)

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRF2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 3H6B4

Product Details anti-TRF2 Antibody

Binding Specificity: AA 324-500

Purpose: TERF2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TERF2 (AA: 324-500) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-TRF2 antibody (ABIN1724941)

Galati, Magdinier, Colasanti, Bauwens, Pinte, Ricordy, Giraud-Panis, Pusch, Savino, Cacchione, Gilson: "TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner." in: PLoS ONE, Vol. 7, Issue 4, pp. e34386, (2012) (PubMed).

Diehl, Idowu, Kimmelshue, York, Jackson-Cook, Turner, Holt, Elmore: "Elevated TRF2 in advanced breast cancers with short telomeres." in: Breast cancer research and treatment, Vol. 127, Issue 3, pp. 623-30, (2011) (PubMed).

Target Details for TRF2

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Alternative Name: TERF2

Background: This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.

Molecular Weight: 55.6 kDa

UniProt: Q15554

Pathways: Cell Division Cycle, Telomere Maintenance