Axin antibody (C-Term)

Catalog No. ABIN1732156

This Goat Polyclonal antibody specifically detects Axin in ELISA and IHC (p). It exhibits reactivity toward Human, Mouse, Rat, Cow and Dog.

Quick Overview for Axin antibody (C-Term) (ABIN1732156)

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Reactivity: Human, Mouse, Rat, Cow, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This Axin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Axin Antibody

Binding Specificity: C-Term

Specificity: Reacts with the C-terminus part of human AXIN1

Cross-Reactivity: Mouse (Murine), Cow (Bovine), Dog (Canine), Rat (Rattus)

Cross-Reactivity (Details): Cross reacts with bovine, canine, mouse and rat protein. This antibody is expected to recognise both reported isoforms.

Purification: Antigen affinity purified

Immunogen: Synthetic peptide C-FEEKIIGKVEKVD from the C-terminus of human AXIN1 (NP_003493.1, NP_851393.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Baboon (100%), Monkey (100%), Marmoset (100%)

Application Details

Application Notes:

Working dilution: ELISA (1:128000), IHC-P (3.75 μg/mL)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: TBS, pH 7.3, BSA 0.5 % , Sodium azide 0.02 %

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Minimize freezing and thawing.

Target Details for Axin

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Alternative Name: AXIN1

Background: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

UniProt: O15169

Pathways: WNT Signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling