BIM antibody (AA 22-40)

Catalog No. ABIN1732339

This Rabbit Polyclonal antibody specifically detects BIM in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for BIM antibody (AA 22-40) (ABIN1732339)

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-BIM Antibody

Binding Specificity: AA 22-40

Specificity: Reacts with the internal domain of human, mouse and rat Bim.

Purification: Purified

Immunogen: Peptide corresponding to aa 22-40 of human Bim. The sequence is identical to that of mouse and is different by one amino acid from that of rat.

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB(1 μg/mL) IHC(10 - 20 μg/mL)

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BIM

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Alternative Name: Bim

Background: Bim/BOD interacts with diverse members in the prosurvival Bcl-2 subfamily including Bcl-2, Bcl-xL, and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

Bcl-2-like protein 11, Bcl2-L-11 Bcl2-interacting mediator of cell death Gene name: BCL2L11, BIM, BAM, BOD

Gene ID: 10018

UniProt: O43521

Pathways: PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity