F12 antibody

Catalog No. ABIN1734212

Product Details anti-F12 Antibody

Target: F12 (Coagulation Factor XII (F12))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This F12 antibody is un-conjugated

Application: ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with human F12 / Factor XII

Cross-Reactivity (Details): Specific for Factor XII as demonstrated by immunodiffusion. A single precipitin arc was obtained with normal plasma and no reaction was observed with F. XII-deficient plasma.

Purification: Purified

Immunogen: Activated human Factor XII (F XIIa) purified from plasma.

Isotype: IgG

Application Details

Application Notes:

Working dilution: IHC-P (5 μg/mL)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 10 mM HEPES, pH 7.4, 0.15 M NaCl, 50 % glycerol.

Storage: 4 °C/-20 °C

Storage Comment: Long term: -20°C, Short term: +4°C. Avoid repeat freeze-thaw cycles.

Target Details for F12

Target: F12 (Coagulation Factor XII (F12))

Alternative Name: F12 / Factor XII (F12 Products)

Synonyms: HAE3 antibody, HAEX antibody, HAF antibody, FXII antibody, coagulation factor XII antibody, coagulation factor XII (Hageman factor) antibody, F12 antibody

Background: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

Pathways: Complement System