EPH Receptor A2 antibody

Catalog No. ABIN179724

This anti-EPH Receptor A2 antibody is a Mouse Monoclonal antibody detecting EPH Receptor A2 in FACS, IF and cELISA. Suitable for Human.

Quick Overview for EPH Receptor A2 antibody (ABIN179724)

Target: EPH Receptor A2 (EPHA2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPH Receptor A2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Cell-ELISA (cELISA)

Clone: Kalpha-5H5

Product Details anti-EPH Receptor A2 Antibody

Specificity: Anti-human EphA2

Purification: Protein G

Immunogen: genetic immunisation with cDNA encoding human EphA2

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: 1.2 µg/10^6 cells
Immunofluorescence: 1 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Comment:

Synonyms: Eph receptor tyrosine kinase A2

Restrictions: For Research Use only

Handling

Concentration: 2 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

Target Details for EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Alternative Name: EPHA2

Background: EphA2 (Ephrin receptor tyrosine kinase A2) belongs to the Ephrin tyrosine receptor familiy, the largest receptor tyrosine kinase family of transmembrane proteins. It encodes a 130 kDA transmembrane protein which is primarily found in adult human epithelial cells. Eph receptors and their ephrin ligands are important mediators of cell-cell communication and play roles in embryonic patterning, neuronal targeting, and vascular development during normal embryogenesis. The Eph family of receptor tyrosine kinases is frequently overexpressed in a wide variety of cancers and tumor cell lines. In particular, EphA2 is overexpressed in prostate, lung and colon cancers and 40% of breast cancers and it represent an attractive potential target for drug design.

UniProt: P29317

Pathways: RTK Signaling