FOLR1 antibody

Catalog No. ABIN180849

The Mouse Monoclonal anti-FOLR1 antibody (Clone SF55 (BGN-1210-55)) (ABIN180849) specifically detects FOLR1 in EIA. The antibody is reactive with Human and Cow samples.

Quick Overview for FOLR1 antibody (ABIN180849)

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Reactivity: Human, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOLR1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: SF55 (BGN-1210-55)

Product Details anti-FOLR1 Antibody

Specificity: This antibody reacts with Folate Binding Protein (FBP) a 30 kDa protein with a high affinity for folate and several reduced folic acid derivatives, that mediates the intracelullar delivery of 5-Methyl-Tetrahydrofolate. Membrane bound and soluble forms of a high affinity FBP have been found in kidney, placenta, serum, milk, and several cell lines.

Characteristics: Synonyms: FR-alpha, Folate receptor 1, MOv18, KB cells FBP, FOLR1, FOLR, Adult folate-binding protein,Ovarian tumor-associated antigen MOv18

Purification: Affinity Chromatography on Protein G

Immunogen: Folate binding protein from bovine milk.

Isotype: IgG1

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Alternative Name: Folate Receptor alpha

Background: Folate Binding Protein, has a high affinity for folic acid and for several reduced folic acid derivatives and mediates delivery of 5 methyltetrahydrofolate to the interior of cells. Membrane bound and soluble forms of a high affinity folate binding protein have been found in kidney, placenta, serum, milk, and in several cell lines. The 2 forms have similar binding characteristics for folates, are immunologically crossreactive, and, based upon limited amino acid sequence data, are nearly identical. There may be a precursor product relationship between the membrane and soluble forms, the membrane form having additional amino acid residues and greater molecular weight. The membrane form has been shown to mediate the transport of folate in cells grown in physiologic concentrations of folate. A function for the soluble form, which is found in serum, milk, and urine, has not been identified.Synonyms: Adult folate-binding protein, FOLR, FOLR1, FR-alpha, Folate receptor 1, KB cells FBP, MOv18, Ovarian tumor-associated antigen MOv18

Gene ID: 2348

UniProt: P15328

Pathways: Dicarboxylic Acid Transport