C4BPA antibody

Catalog No. ABIN181109

Product Details anti-C4BPA Antibody

Target: C4BPA (Complement Component 4 Binding Protein, alpha (C4BPA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C4BPA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes complement component 4 binding protein (C4bp).

Characteristics: Synonyms: C4BPA, C4BP, Proline-rich protein, PRP

Purification: Affinity Chromatography on Protein A.

Immunogen: Native Human C4 binding protein. Genename: C4BP

Clone: 10-07-14

Isotype: IgG2b

Application Details

Application Notes: ELISA. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline, pH 8.4 containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for C4BPA

Target: C4BPA (Complement Component 4 Binding Protein, alpha (C4BPA))

Alternative Name: C4b-Binding Protein alpha (C4BPA Products)

Synonyms: CRES antibody, c4bp antibody, C4BP antibody, PRP antibody, complement component 4 binding protein, alpha chain antibody, C4b-binding protein alpha chain antibody, complement component 4 binding protein alpha antibody, complement component 4 binding protein, alpha antibody, LOC419851 antibody, c4bp antibody, C4BPA antibody, C4bpa antibody

Background: There are three variants of C4bp, composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.Synonyms: C4BP, C4BPA, PRP, Proline-rich protein

Gene ID: 722

UniProt: P04003

Pathways: Complement System