SIGLEC10 antibody

Catalog No. ABIN1819172

The Mouse Monoclonal anti-SIGLEC10 antibody has been validated for FACS. It is suitable to detect SIGLEC10 in samples from Human.

Quick Overview for SIGLEC10 antibody (ABIN1819172)

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC10 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 5G6

Product Details anti-SIGLEC10 Antibody

Specificity: Clone 5G6 specifically recognizes human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9, see for details.

Purification: Protein G purified

Immunogen: Recombinant human Siglec-10, fused with the Fc region of human IgG.

Type of Immunogen: Recombinant protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for SIGLEC10

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Alternative Name: SIGLEC10 / SIGLEC-10

Background: Name/Gene ID: SIGLEC10

Synonyms: SIGLEC10, SIGLEC-10, Siglec-like gene 2, Siglec-like protein 2, PRO940, SLG2

Gene ID: 89790

UniProt: Q96LC7