P2RX7 antibody

Catalog No. ABIN6796397

This Rat Monoclonal antibody specifically detects P2RX7 in FACS and IF. It exhibits reactivity toward Mouse.

Quick Overview for P2RX7 antibody (ABIN6796397)

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This P2RX7 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: Hano43

Product Details anti-P2RX7 Antibody

Specificity: Recognizes the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.

Purification: Protein G purified

Immunogen: A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.

Type of Immunogen: Cells

Isotype: IgG2b

Application Details

Application Notes: Approved: Flo (1:25 - 1:200), IF

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for P2RX7

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Alternative Name: P2RX7 / P2X7

Background: Name/Gene ID: P2RX7
Subfamily: P2X receptor
Family: Ion Channel

Synonyms: P2RX7, ATP receptor, p2X purinoceptor 7, p2X receptor 7, p2X7 purinoceptor, p2Z receptor, Purinergic receptor, p2RX7, p2X7, p2X7 receptor

Gene ID: 5027

UniProt: Q99572

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis