CD11b antibody (PE)

Catalog No. ABIN1820250

This anti-CD11b antibody is a Rat Monoclonal antibody detecting CD11b in FACS. Suitable for Human and Mouse.

Quick Overview for CD11b antibody (PE) (ABIN1820250)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD11b antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 5C6

Product Details anti-CD11b Antibody (PE)

Specificity: Recognizes CD11b, also known as the integrin alpha M chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Clone 5C6 immunoprecipitates a heterodimer of 165 and 95kD. Clone 5C6 also exhibits various functional properties, reportedly inhibiting adhesion in vitro and inflammatory recruitment in vivo. This clone also inhibits delayed hypersensitivity, potentiates bacterial infections and inhibits type 1 diabetes.

Purification: Ion exchange chromatography

Immunogen: Thioglycollate-elicited Peritoneal Macrophages (TPM).

Isotype: IgG2b

Application Details

Application Notes: Approved: Flo (1:10)

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 1 % BSA, 5 % sucrose

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing. Protect from light.

Storage: 4 °C,-20 °C

Storage Comment: Short term: store at 4°C. Long term: -20°C. Avoid freeze-thaw cycles. Protect from light.

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: ITGAM / CD11b

Background: Name/Gene ID: ITGAM
Family: Integrin

Synonyms: ITGAM, Antigen CD11b (p170), CD11B, CD11b antigen, CR3A, Integrin alpha-M, MAC-1, MO1A, Neutrophil adherence receptor, MAC1A, SLEB6, CR-3 alpha chain

Gene ID: 3684

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation