APOA5 antibody (AA 20-363)

Catalog No. ABIN1842850

Product Details anti-APOA5 Antibody

Target: APOA5 (Apolipoprotein A-V (APOA5))

Binding Specificity: AA 20-363

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOA5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human APOA5 (AA: 20-363) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Target Details for APOA5

Target: APOA5 (Apolipoprotein A-V (APOA5))

Alternative Name: Apoa5 (APOA5 Products)

Background: Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor- agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.

Molecular Weight: 41 kDa

Gene ID: 116519

UniProt: Q6Q788

Pathways: Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism