PDE1B antibody (AA 370-536)

Catalog No. ABIN1845413

The Mouse Monoclonal anti-PDE1B antibody is suitable to detect PDE1B in samples from Human, Mouse and Monkey. It has been validated for WB, ELISA and FACS.

Quick Overview for PDE1B antibody (AA 370-536) (ABIN1845413)

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Reactivity: Human, Mouse, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDE1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PDE1B Antibody

Binding Specificity: AA 370-536

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PDE1B (AA: 370-536) expressed in E. coli.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Target Details for PDE1B

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Alternative Name: PDE1B

Background: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily.Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex.This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate.cAMP and cGMP function as key regulators of many important physiological processes.Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 61.4 kDa

Gene ID: 5153

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma