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VAV1 antibody (AA 121-324)

This anti-VAV1 antibody is a Mouse Monoclonal antibody detecting VAV1 in WB, ELISA and FACS. Suitable for Human.
Catalog No. ABIN1845807

Quick Overview for VAV1 antibody (AA 121-324) (ABIN1845807)

Target

See all VAV1 Antibodies
VAV1 (Vav 1 Oncogene (VAV1))

Reactivity

  • 67
  • 38
  • 24
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 66
  • 4
Mouse

Clonality

  • 65
  • 5
Monoclonal

Conjugate

  • 51
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
This VAV1 antibody is un-conjugated

Application

  • 50
  • 35
  • 18
  • 9
  • 8
  • 8
  • 7
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • Binding Specificity

    • 15
    • 14
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 121-324

    Purification

    Purified antibody

    Immunogen

    Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.

    Isotype

    IgG1
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1.0 mg/mL

    Buffer

    PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
  • Target

    VAV1 (Vav 1 Oncogene (VAV1))

    Alternative Name

    VAV1

    Background

    The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

    Molecular Weight

    98.3 kDa

    Gene ID

    7409

    UniProt

    P15498

    Pathways

    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling
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