SQSTM1 antibody (AA 232-356)

Catalog No. ABIN1846090

This Mouse Monoclonal antibody specifically detects SQSTM1 in WB, IHC, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for SQSTM1 antibody (AA 232-356) (ABIN1846090)

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SQSTM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Product Details anti-SQSTM1 Antibody

Binding Specificity: AA 232-356

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SQSTM1 (AA: 232-356) expressed in E. coli.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Target Details for SQSTM1

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Alternative Name: SQSTM1

Background: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway.The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals.Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene.Mutations in this gene result in sporadic and familial Paget disease of bone.

Molecular Weight: 47.7 kDa

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy