ATP1B2 antibody (C-Term)

Catalog No. ABIN1881088

This Rabbit Polyclonal antibody specifically detects ATP1B2 in WB. It exhibits reactivity toward Human. It has been mentioned in 5+ publications

Quick Overview for ATP1B2 antibody (C-Term) (ABIN1881088)

Target: ATP1B2 (ATPase, Na+/K+ Transporting, beta 2 Polypeptide (ATP1B2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP1B2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41560

Product Details anti-ATP1B2 Antibody

Binding Specificity: AA 247-276, C-Term

Predicted Reactivity: B, M, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATP1B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human ATP1B2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ATP1B2 antibody (ABIN1881088)

Boer, Troost, Timmermans, van Rijen, Spliet, Aronica: "Pi3K-mTOR signaling and AMOG expression in epilepsy-associated glioneuronal tumors." in: Brain pathology (Zurich, Switzerland), Vol. 20, Issue 1, pp. 234-44, (2010) (PubMed).

Floyd, Wray, Quenby, Martín-Vasallo, Mobasheri: "Expression and distribution of Na, K-ATPase isoforms in the human uterus." in: Reproductive sciences (Thousand Oaks, Calif.), Vol. 17, Issue 4, pp. 366-76, (2010) (PubMed).

Guey, García-Closas, Murta-Nascimento, Lloreta, Palencia, Kogevinas, Rothman, Vellalta, Calle, Marenne, Tardón, Carrato, García-Closas, Serra, Silverman, Chanock, Real, Malats: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, (2010) (PubMed).

Tokhtaeva, Sachs, Vagin: "Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum." in: Biochemistry, Vol. 48, Issue 48, pp. 11421-31, (2009) (PubMed).

Hosgood, Menashe, He, Chanock, Lan: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, (2009) (PubMed).

Target Details for ATP1B2

Target: ATP1B2 (ATPase, Na+/K+ Transporting, beta 2 Polypeptide (ATP1B2))

Alternative Name: ATP1B2

Background: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit.

Molecular Weight: 33367

NCBI Accession: NP_001669

UniProt: P14415

Pathways: Thyroid Hormone Synthesis