CPSF6 antibody (N-Term)

Catalog No. ABIN1881225

Cited in 5+ publications. The Rabbit Polyclonal anti-CPSF6 antibody (Clone RB42780) (ABIN1881225) specifically detects CPSF6 in WB. The antibody is reactive with Human samples.

Quick Overview for CPSF6 antibody (N-Term) (ABIN1881225)

Target: CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPSF6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42780

Product Details anti-CPSF6 Antibody

Binding Specificity: AA 23-51, N-Term

Predicted Reactivity: B, C, Zf, M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CPSF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-51 amino acids from the N-terminal region of human CPSF6.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CPSF6 antibody (ABIN1881225)

Lee, Ambrose, Martin, Oztop, Mulky, Julias, Vandegraaff, Baumann, Wang, Yuen, Takemura, Shelton, Taniuchi, Li, Sodroski, Littman, Coffin, Hughes, Unutmaz, Engelman, KewalRamani: "Flexible use of nuclear import pathways by HIV-1." in: Cell host & microbe, Vol. 7, Issue 3, pp. 221-33, (2010) (PubMed).

Ruepp, Aringhieri, Vivarelli, Cardinale, Paro, Schümperli, Barabino: "Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export." in: Molecular biology of the cell, Vol. 20, Issue 24, pp. 5211-23, (2009) (PubMed).

Xin, Rual, Hirozane-Kishikawa, Hill, Vidal, Boone, Thierry-Mieg: "Shifted Transversal Design smart-pooling for high coverage interactome mapping." in: Genome research, Vol. 19, Issue 7, pp. 1262-9, (2009) (PubMed).

Maggi, Kuchenruether, Dadey, Schwope, Grisendi, Townsend, Pandolfi, Weber: "Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome." in: Molecular and cellular biology, Vol. 28, Issue 23, pp. 7050-65, (2008) (PubMed).

Gudbjartsson, Walters, Thorleifsson, Stefansson, Halldorsson, Zusmanovich, Sulem, Thorlacius, Gylfason, Steinberg, Helgadottir, Ingason, Steinthorsdottir, Olafsdottir, Olafsdottir, Jonsson et al.: "Many sequence variants affecting diversity of adult human height." in: Nature genetics, Vol. 40, Issue 5, pp. 609-15, (2008) (PubMed).

Target Details for CPSF6

Target: CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))

Alternative Name: CPSF6

Background: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

Molecular Weight: 59210

NCBI Accession: NP_008938

UniProt: Q16630