ENPP1 antibody (N-Term)

Catalog No. ABIN1881296

There are 5+ publications for this product available. The Rabbit Polyclonal anti-ENPP1 antibody is suitable to detect ENPP1 in samples from Human. It has been validated for WB.

Quick Overview for ENPP1 antibody (N-Term) (ABIN1881296)

Target: ENPP1 (Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ENPP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41733

Product Details anti-ENPP1 Antibody

Binding Specificity: AA 6-34, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ENPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human ENPP1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ENPP1 antibody (ABIN1881296)

Ermakov, Rosenbaum, Malkin, Livshits: "Family-based study of association between ENPP1 genetic variants and craniofacial morphology." in: Annals of human biology, Vol. 37, Issue 6, pp. 754-66, (2010) (PubMed).

Wang, Peng, Qu, Huang: "[Association and meta-analysis of ENPP1 K121Q with type 2 diabetes in Han Chinese.]." in: Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, Vol. 32, Issue 8, pp. 808-16, (2010) (PubMed).

Cruz, Valladares-Salgado, Garcia-Mena, Ross, Edwards, Angeles-Martinez, Ortega-Camarillo, de la Peña, Burguete-Garcia, Wacher-Rodarte, Ambriz, Rivera, Dartote, Peralta, Parra, Kumate: "Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City." in: Diabetes/metabolism research and reviews, Vol. 26, Issue 4, pp. 261-70, (2010) (PubMed).

Moehlecke, Kramer, Leitão, Krahe, Balbosco, Azevedo, Gross, Canani: "[ENPP1 K121Q polymorphism and ischemic heart disease in diabetic patients]." in: Arquivos brasileiros de cardiologia, Vol. 94, Issue 2, pp. 157-61, 168-73, 159-63, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Target Details for ENPP1

Target: ENPP1 (Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1))

Alternative Name: ENPP1

Background: This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.

Molecular Weight: 104924

NCBI Accession: NP_006199

UniProt: P22413

Pathways: Regulation of Carbohydrate Metabolic Process