GATM antibody (C-Term)

Catalog No. ABIN1881365

There are 3+ publications for this product available. The Rabbit Polyclonal anti-GATM antibody is suitable to detect GATM in samples from Human. It has been validated for WB.

Quick Overview for GATM antibody (C-Term) (ABIN1881365)

Target: GATM (Glycine Amidinotransferase (L-Arginine:glycine Amidinotransferase) (GATM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GATM antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41023

Product Details anti-GATM Antibody

Binding Specificity: AA 350-378, C-Term

Predicted Reactivity: B, Pr, M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GATM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-378 amino acids from the C-terminal region of human GATM.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GATM antibody (ABIN1881365)

Köttgen, Glazer, Dehghan, Hwang, Katz, Li, Yang, Gudnason, Launer, Harris, Smith, Arking, Astor, Boerwinkle, Ehret, Ruczinski: "Multiple loci associated with indices of renal function and chronic kidney disease." in: Nature genetics, Vol. 41, Issue 6, pp. 712-7, (2010) (PubMed).

Köttgen, Pattaro, Böger, Fuchsberger, Olden, Glazer, Parsa, Gao, Yang, Smith, OConnell, Li, Schmidt, Tanaka, Isaacs, Ketkar, Hwang, Johnson, Dehghan, Teumer, Paré, Atkinson, Zeller, Lohman et al.: "New loci associated with kidney function and chronic kidney disease...." in: Nature genetics, Vol. 42, Issue 5, pp. 376-84, (2010) (PubMed).

Lion-François, Cheillan, Pitelet, Acquaviva-Bourdain, Bussy, Cotton, Guibaud, Gérard, Rivier, Vianey-Saban, Jakobs, Salomons, des Portes: "High frequency of creatine deficiency syndromes in patients with unexplained mental retardation." in: Neurology, Vol. 67, Issue 9, pp. 1713-4, (2006) (PubMed).

Target Details for GATM

Target: GATM (Glycine Amidinotransferase (L-Arginine:glycine Amidinotransferase) (GATM))

Alternative Name: GATM

Background: This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.

Molecular Weight: 48455

NCBI Accession: NP_001473

UniProt: P50440