IKBKB antibody (pSer177)

Catalog No. ABIN1881450

Cited in 5+ publications. The Rabbit Polyclonal anti-IKBKB antibody (Clone RB40664) (ABIN1881450) specifically detects IKBKB in DB. The antibody is reactive with Human samples.

Quick Overview for IKBKB antibody (pSer177) (ABIN1881450)

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKBKB antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB40664

Product Details anti-IKBKB Antibody

Binding Specificity: pSer177

Predicted Reactivity: B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S177 of human IKKB.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-IKBKB antibody (ABIN1881450)

Yatherajam, Banerjee, McCorkell, Solt, Hanson, Madge, Kang, Worley, Orange, May: "Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 5, pp. 2665-9, (2010) (PubMed).

Kenneth, Mudie, Rocha: "IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function." in: The EMBO journal, Vol. 29, Issue 17, pp. 2966-78, (2010) (PubMed).

Zhao, Li, Chen: "CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24372-80, (2010) (PubMed).

Niida, Tanaka, Kamitani: "Downregulation of active IKK beta by Ro52-mediated autophagy." in: Molecular immunology, Vol. 47, Issue 14, pp. 2378-87, (2010) (PubMed).

Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, (2010) (PubMed).

Target Details for IKBKB

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Alternative Name: IKKB

Background: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

Molecular Weight: 86564

NCBI Accession: NP_001177649, NP_001229707, NP_001547

UniProt: O14920

Pathways: NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins