PDX1 antibody (AA 43-72)

Catalog No. ABIN1881463

This Rabbit Polyclonal antibody specifically detects PDX1 in WB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for PDX1 antibody (AA 43-72) (ABIN1881463)

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDX1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB16670

Product Details anti-PDX1 Antibody

Binding Specificity: AA 43-72

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from human IPF.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PDX1 antibody (ABIN1881463)

Ma, Chen, Wang, Xia, Zhu, Liang, Gu, Qiao, Dai, Zou, Li, Zhang, Lan, Wong: "Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1327-33, (2008) (PubMed).

Target Details for PDX1

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Alternative Name: IPF

Background: IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Molecular Weight: 30771

NCBI Accession: NP_000200

UniProt: P52945

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location